Journal
STEM CELLS TRANSLATIONAL MEDICINE
Volume 1, Issue 5, Pages 359-372Publisher
WILEY
DOI: 10.5966/sctm.2011-0021
Keywords
Adult stem cells; Cytokines; Mesenchymal stem cells; Placenta; Telomerase
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Funding
- Jean J. Deleage Ph.D. and Josette Deleage Foundation
- Bay View Eagles Lodge
- CHORI Jordan Family Foundation
- CHORI Ventures
- NIH [HL-070583, 1R43HL108327, 1R43DK091963, HL-51856, HL-51854, HL-093026, P40RR017447]
- Foundation of Anesthesia Education Research
- CHORI
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We describe human chorionic mesenchymal stem cell (hCMSC) lines obtained from the chorion of human term placenta with high therapeutic potential in human organ pathology. hCMSCs propagated for more than 100 doublings without a decrease in telomere length and with no telomerase activity. Cells were highly positive for the embryonic stem cell markers OCT-4, NANOG, SSEA-3, and TRA-1-60. In vitro, cells could be differentiated into neuron-like cells (ectoderm), adipocytes, osteoblasts, endothelial-like cells (mesoderm), and hepatocytes (endoderm) derivatives of all three germ layers. hCMSCs effectively facilitated repair of injured epithelium as demonstrated in an ex vivo-perfused human lung preparation injured by Escherichia coli endotoxin and in in vitro human lung epithelial cultures. We conclude that the chorion of human term placenta is an abundant source of multipotent stem cells that are promising candidates for cell-based therapies. STEM CELLS TRANSLATIONAL MEDICINE 2012;1: 359-372
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