Journal
STEM CELLS TRANSLATIONAL MEDICINE
Volume 1, Issue 1, Pages 51-58Publisher
WILEY
DOI: 10.5966/sctm.2011-0019
Keywords
Mesenchymal stem cells; Immunosuppression; Cell-based therapy; Translational medicine
Categories
Funding
- Ministry of Science and Technology of China [2010CB945600, 2008GR0606, 1027J11291, 2009ZX09503-024]
- Chinese Academy of Science [KSCX1-YW-22, KSCX2-YW-R-245, XDA01040000-Y11HJ11291]
- National Science and Technology Project of China [31010103908]
- National Institutes of Health (USA) [DE014913, DE019932, GM866889]
- Robert Wood Johnson Foundation [67038]
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE019932] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM866889] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Mesenchymal stem cells (MSCs) are emerging as a promising therapeutic approach of cell-based therapy for a wide range of autoimmune disorders and degenerative diseases. In preclinical and clinical studies, MSCs have been shown to be highly efficient in treating graft-versus-host disease, systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, myocardial infarction, liver cirrhosis, inflammatory bowel disease, and other disorders. The underlying therapeutic mechanisms of MSCs include their homing efficiency to the tissue injury sites, their differentiation potential, their capability to produce a large amount of trophic factors, and their immunomodulatory effect. Because tissue damage sites are complicated milieus with distinct types of inflammatory cells and factors, available data have demonstrated that the properties of MSCs could be fundamentally influenced by the inflammatory elements. Thus, an understanding of the interaction between MSCs and the inflammatory microenvironment will provide critical information in revealing the precise in vivo mechanisms of MSC-mediated therapeutic effects and designing more practical protocols for clinical use of these cells. STEM CELLS TRANSLATIONAL MEDICINE 2012;1:51-58
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available