Aza-Michael Addition of γ-Aminopropylsilatranes to Substituted N-Phenylmaleimides: Design and Synthesis of a Heterocyclic Amine Receptor and Their Preliminary Antimicrobial Studies

An efficient method for C-N bond formation via aza-Michael addition of gamma-aminopropylsilatranes to substituted N-phenylmaleimides under mild conditions is described. The five receptors enclosing the maleimide moiety have been synthesized by the aza-Michael addition to strong nucleophile gamma-aminopropylsilatrane producing silatranes possessing substituted N-phenylsuccinimide at the axial position without any catalyst. All the compounds have been characterized by elemental analysis, spectro-scopic techniques and thermo-gravimetric analysis. The synthesized compounds have been screened for possible antimicrobial properties and results have shown modest activity.