Journal
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 11, Issue -, Pages 869-874Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.11.97
Keywords
antimicrobial activities; D-glucosamine; diosgenin glycosylation; N-alkylation
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Funding
- European Union within the European Regional Development Fund [UDA-POIG.01.01.02-14-102/09]
- Ministry of Science and Higher Education [DS/530-8457-D603-15]
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Diosgenyl 2-amino-2-deoxy-beta-D-glucopyranoside is a synthetic saponin exhibiting attractive pharmacological properties. Different pathways tested by us to obtain this glycoside are summarized here. Moreover, the synthesis of N-alkyl and N,N-dialkyl derivatives of the glucopyranoside is presented. Evaluation of antibacterial and antifungal activities of these derivatives indicates that they have no inhibitory activity against Gram-negative bacteria, whereas many of the tested N-alkyl saponins were found to inhibit the growth of Gram-positive bacteria and human pathogenic fungi.
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