Related references
Note: Only part of the references are listed.Encoding and Decoding Cellular Information through Signaling Dynamics
Jeremy E. Purvis et al.
CELL (2013)
Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2
Sean J. Humphrey et al.
CELL METABOLISM (2013)
mTORC1 couples immune signals and metabolic programming to establish Treg-cell function
Hu Zeng et al.
NATURE (2013)
Sinl phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis
Pengda Liu et al.
NATURE CELL BIOLOGY (2013)
Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels tomTORC1
Liron Bar-Peled et al.
CELL (2012)
mTOR Signaling in Growth Control and Disease
Mathieu Laplante et al.
CELL (2012)
Decoding the Insulin Signal
Jeremy E. Purvis et al.
MOLECULAR CELL (2012)
A Two-Dimensional ERK-AKT Signaling Code for an NGF-Triggered Cell-Fate Decision
Jia-Yun Chen et al.
MOLECULAR CELL (2012)
A unifying model for mTORC1-mediated regulation of mRNA translation
Carson C. Thoreen et al.
NATURE (2012)
p53 Dynamics Control Cell Fate
Jeremy E. Purvis et al.
SCIENCE (2012)
Amino acids and mTORC1: from lysosomes to disease
Alejo Efeyan et al.
TRENDS IN MOLECULAR MEDICINE (2012)
Activation of mTORC2 by Association with the Ribosome
Vittoria Zinzalla et al.
CELL (2011)
Regulation of TFEB and V-ATPases by mTORC1
Samuel Pena-Llopis et al.
EMBO JOURNAL (2011)
Evolution of the TOR Pathway
Teunis J. P. van Dam et al.
JOURNAL OF MOLECULAR EVOLUTION (2011)
mTOR: from growth signal integration to cancer, diabetes and ageing
Roberto Zoncu et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase
Roberto Zoncu et al.
SCIENCE (2011)
Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
Yonghao Yu et al.
SCIENCE (2011)
The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
Peggy P. Hsu et al.
SCIENCE (2011)
Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
Yasemin Sancak et al.
CELL (2010)
S6K1 Plays a Critical Role in Early Adipocyte Differentiation
Larissa S. Carnevalli et al.
DEVELOPMENTAL CELL (2010)
Fat Cell-Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism
Anil Kumar et al.
DIABETES (2010)
Rictor Forms a Complex with Cullin-1 to Promote SGK1 Ubiquitination and Destruction
Daming Gao et al.
MOLECULAR CELL (2010)
Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition
Calvin K. Yip et al.
MOLECULAR CELL (2010)
LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
R. J. Shaw
ACTA PHYSIOLOGICA (2009)
Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1
Christian C. Dibble et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Molecular mechanisms of mTOR-mediated translational control
Xiaoju Max Ma et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
Juan M. Garcia-Martinez et al.
BIOCHEMICAL JOURNAL (2008)
Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration
Pazit Polak et al.
CELL METABOLISM (2008)
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
Tsuneo Ikenoue et al.
EMBO JOURNAL (2008)
AMPK phosphorylation of raptor mediates a metabolic checkpoint
Dana M. Gwinn et al.
MOLECULAR CELL (2008)
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
Yasemin Sancak et al.
SCIENCE (2008)
AKT/PKB signaling: Navigating downstream
Brendan D. Manning et al.
CELL (2007)
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
Emilie Vander Haar et al.
NATURE CELL BIOLOGY (2007)
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα but not S6K1
David A. Guertin et al.
DEVELOPMENTAL CELL (2006)
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
Qian Yang et al.
GENES & DEVELOPMENT (2006)
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
Estela Jacinto et al.
CELL (2006)
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
Maria A. Frias et al.
CURRENT BIOLOGY (2006)
mTOR and cancer: insights into a complex relationship
David M. Sabatini
NATURE REVIEWS CANCER (2006)
Turnover of the active fraction of IRS1 involves Raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis
O. Jameel Shah et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
DD Sarbassov et al.
MOLECULAR CELL (2006)
TOR signaling in growth and metabolism
S Wullschleger et al.
CELL (2006)
TOR signaling in growth and metabolism
Stephan Wullschleger et al.
CELL (2006)
AKT signaling in normal and malignant cells
JR Testa et al.
ONCOGENE (2005)
Molecular organization of target of rapamycin complex 2
S Wullschleger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2
BD Manning et al.
GENES & DEVELOPMENT (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
P Gual et al.
BIOCHIMIE (2005)
Dysregulation of the TSC-mTOR pathway in human disease
K Inoki et al.
NATURE GENETICS (2005)
Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function
N Oshiro et al.
GENES TO CELLS (2004)
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
DD Sarbassov et al.
CURRENT BIOLOGY (2004)
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
LS Harrington et al.
JOURNAL OF CELL BIOLOGY (2004)
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
E Jacinto et al.
NATURE CELL BIOLOGY (2004)
TSC2 mediates cellular energy response to control cell growth and survival
K Inoki et al.
CELL (2003)
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
K Inoki et al.
NATURE CELL BIOLOGY (2002)
MTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
DH Kim et al.
CELL (2002)
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-Kinase/Akt pathway
BD Manning et al.
MOLECULAR CELL (2002)
Share Paper
