Journal
PROTEIN & CELL
Volume 3, Issue 4, Pages 246-250Publisher
HIGHER EDUCATION PRESS
DOI: 10.1007/s13238-012-2918-4
Keywords
induced pluripotent stem cells; hepatocytes; disease modeling; drug development; cell therapy
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Funding
- Sanofi-Aventis
- The Helmsley Charitable Trust
- The Ellison Medical Foundation
- 100 Talents Program of the Chinese Academy of Sciences
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Recent advances in the study of human hepatocytes derived from induced pluripotent stem cells (iPSC) represent new promises for liver disease study and drug discovery. Human hepatocytes or hepatocyte-like cells differentiated from iPSC recapitulate many functional properties of primary human hepatocytes and have been demonstrated as a powerful and efficient tool to model human liver metabolic diseases and facilitate drug development process. In this review, we summarize the recent progress in this field and discuss the future perspective of the application of human iPSC derived hepatocytes.
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