Journal
PROTEIN & CELL
Volume 2, Issue 11, Pages 879-888Publisher
SPRINGEROPEN
DOI: 10.1007/s13238-011-1101-7
Keywords
activator; transcription; co-activator; enhancer; promoter; signal transduction; development
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Funding
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [0843424] Funding Source: National Science Foundation
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Transcriptional activators are required to turn on the expression of genes in a eukaryotic cell. Activators bound to the enhancer can facilitate either the recruitment of RNA polymerase II to the promoter or its elongation. This article examines a few selected issues in understanding activator functions and activation mechanisms.
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