Journal
PROTEIN & CELL
Volume 1, Issue 7, Pages 621-626Publisher
HIGHER EDUCATION PRESS
DOI: 10.1007/s13238-010-0073-3
Keywords
synthetic biology; reduced-genome; secondary metabolite
Categories
Funding
- National Programs for High Technology Research and Development Program (863 Program) [2006AA09Z402, 2007AA09Z443]
- National Basic Research Program of China (973 Program) [2004CB719601]
- National Natural Science Foundation of China [30560001, 30600001, 30700015]
- National Key Technology RD Program [2007BAI26B02]
- National Science & Technology Pillar Program [200703295000-02]
- Important National Science & Technology Specific Projects [2008ZX09401-005, 2009ZX09302-004]
- Science and Technology Planning Project of Guangdong Province, China [2006A50103001]
- Key Project of International Cooperation [2007DFB31620]
- Hundred Talents Program
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Synthetic biology aims to design and build new biological systems with desirable properties, providing the foundation for the biosynthesis of secondary metabolites. The most prominent representation of synthetic biology has been used in microbial engineering by recombinant DNA technology. However, there are advantages of using a deleted host, and therefore an increasing number of biotechnology studies follow similar strategies to dissect cellular networks and construct genome-reduced microbes. This review will give an overview of the strategies used for constructing and engineering reduced-genome factories by synthetic biology to improve production of secondary metabolites.
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