Journal
PROTEIN & CELL
Volume 1, Issue 7, Pages 656-663Publisher
HIGHER EDUCATION PRESS
DOI: 10.1007/s13238-010-0083-1
Keywords
RNF152; RING finger; ubiquitinate; apoptosis
Categories
Funding
- Ministry of Science and Technololgy of China [2006CB504304]
- Ministry of Health of China [008ZX10002-008]
Ask authors/readers for more resources
RING finger protein 152 (RNF152) is a novel RING finger protein and has not been well characterized. We report here that RNF152 is a canonical RING finger protein and has E3 ligase activity. It is polyubiqitinated partly through Lys-48-linked ubiquitin chains in vivo and this phenomenon is dependent on its RING finger domain and transmembrane domain. RNF152 is localized in lysosomes and co-localized with LAMP3, a lysosome marker. Moreover, over-expression of RNF152 in Hela cells induces apoptosis. These results suggest that RNF152 is a lysosome localized E3 ligase with pro-apoptotic activities. It is the first E3 ligase identified so far that is involved in lysosome-related apoptosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available