Journal
POLYMERS
Volume 10, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/polym10090983
Keywords
biomimetic; membrane-coated nanoparticle; immune escape; tumor therapy; homotypic targeting
Categories
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Korean government, MSIP [2016R1A2B4011184]
- Bio and Medical Technology Development Program through the National Research Foundation of Korea (NRF) - Korean government, MSIP [NRF-2017M3A9E2056374]
- Pioneer Research Center Program through the National Research Foundation of Korea - Ministry of Science, ICT and Future Planning [2014M3C1A3053035]
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [2018R1A5A2024181]
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Biomimetic functionalization of nanoparticles through camouflaging with cellular membranes has emerged as a promising strategy for cancer theragnostics. Cellular membranes used for camouflaging nanoparticles are generally isolated from blood cells, immune cells, cancer cells, and stem cells. The camouflaging strategy of wrapping nanoparticles with cellular membranes allows for superior tumor targeting through self-recognition, homotypic targeting and prolonged systematic circulation, thereby aiding in effective tumor therapy. In this review, we emphasized the various types of cellular membrane-camouflaged nanoparticles, their mechanisms in targeted therapy and various biomimetic strategies for anti-cancer therapy.
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