Journal
POLYMERS
Volume 4, Issue 3, Pages 1554-1579Publisher
MDPI
DOI: 10.3390/polym4031554
Keywords
hydrogel; lab-on-a-chip; micromolding; microfluidics; cell encapsulation
Categories
Funding
- National Science Foundation [DMR0847287]
- National Institutes of Health [EB008392, DE019024, HL099073, AR057837, HL092836]
- Office of Naval Research
- Institute for Soldier Nanotechnology
- US Army Corps of Engineers
- U.S. Army Research Office [W911NF-07-D-0004]
- Innovative Medical Tech Co.
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [0847287] Funding Source: National Science Foundation
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Hydrogels in which cells are encapsulated are of great potential interest for tissue engineering applications. These gels provide a structure inside which cells can spread and proliferate. Such structures benefit from controlled microarchitectures that can affect the behavior of the enclosed cells. Microfabrication-based techniques are emerging as powerful approaches to generate such cell-encapsulating hydrogel structures. In this paper we introduce common hydrogels and their crosslinking methods and review the latest microscale approaches for generation of cell containing gel particles. We specifically focus on microfluidics-based methods and on techniques such as micromolding and electrospinning.
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