Journal
POLYMERS
Volume 3, Issue 4, Pages 1673-1683Publisher
MDPI AG
DOI: 10.3390/polym3041673
Keywords
enamine click chemistry; intramolecular collapse; unimolecular polymeric nanoparticles
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Funding
- Basque Excellence Research Center-Materials Physics Center (BERC-MPC)
- Spanish Ministry of Science and Innovation [MAT-22007-63681]
- Diputacion de Gipuzkoa [2011-CIEN-000085-01]
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Click chemistry has become an efficient avenue to unimolecular polymeric nanoparticles through the self-crosslinking of individual polymer chains containing appropriate functional groups. Herein we report the synthesis of ultra-small (7 nm in size) polymethyl methacrylate (PMMA) nanoparticles (NPs) by the metal-free cross-linking of PMMA-precursor chains prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization containing beta-ketoester functional groups. Intramolecular collapse was performed by the one-pot reaction of beta-ketoester moieties with alkyl diamines in tetrahydrofurane at r.t. (i.e., by enamine formation). The collapsing process was followed by size exclusion chromatography and by nuclear magnetic resonance spectroscopy. The size of the resulting PMMA-NPs was determined by dynamic light scattering. Enamine click chemistry increases the synthetic toolbox for the efficient synthesis of metal-free, ultra-small polymeric NPs.
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