4.3 Article

Biologic and Plastic Effects of Experimental Traumatic Brain Injury Treatment Paradigms and Their Relevance to Clinical Rehabilitation

Journal

PM&R
Volume 3, Issue 6, Pages S18-S27

Publisher

WILEY
DOI: 10.1016/j.pmrj.2011.03.017

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Funding

  1. NICHD NIH HHS [R01 HD046700-04, R01 HD069620, R01 HD046700] Funding Source: Medline
  2. NINDS NIH HHS [R01 NS060005, R01 NS060005-04, R01 NS060005-03] Funding Source: Medline

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Neuroplastic changes, whether induced by traumatic brain injury (TBI) or therapeutic interventions, alter neurobehavioral outcome. Here we present several treatment strategies that have been evaluated by using experimental TBI models and discuss potential mechanisms of action (ie, plasticity) and how such changes affect function. PM R 2011;3:S18-S27

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