Journal
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 11, Issue -, Pages 875-883Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.11.98
Keywords
design of experiment (DOE); 1,4-dithiane-2,5-diol; Gewald reaction; thiazole; thiophene
Categories
Funding
- Royal Society
- Syngenta
- Erasmus Programme of European Union
- Engineering and Physical Sciences Research Council [1227235] Funding Source: researchfish
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The synthesis of thiazoles and thiophenes starting from nitriles, via a modified Gewald reaction has been studied for a number of different substrates. 1,4-Dithiane-2,5-diol was used as the aldehyde precursor to give either 2-substituted thiazoles or 2-substituted aminothiophenes depending on the substitution of the a-carbon to the cyano group.
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