Journal
OPHTHALMIC SURGERY LASERS & IMAGING RETINA
Volume 46, Issue 5, Pages 513-521Publisher
SLACK INC
DOI: 10.3928/23258160-20150521-02
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Funding
- Alexion Pharmaceuticals
- Carl Zeiss Meditec (Dublin, California)
- Macula Vision Research Foundation
- Research to Prevent Blindness
- Feig Family Foundation
- Emma Clyde Hodge Memorial Foundation
- National Eye Institute [R01EY024158, P30EY014801]
- Carl Zeiss Meditec
- Acucela
- Advanced Cell Technology
- GlaxoSmithKline
- Bayer
- Genentech
- Allergan
- Optos
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BACKGROUND AND OBJECTIVE: To compare subfoveal choroidal thickness (CT) measurements in eyes with nonexudative age-related macular degeneration (AMD) in the presence or absence of reticular pseudodrusen (RPD). PATIENTS AND METHODS: Subfoveal CT measurements obtained from patients with AMD enrolled in the COMPLETE study (30 drusen-only eyes and 30 eyes with geographic atrophy [GA]) were compared with an age-distributed normal control group. Multimodal images were evaluated to detect the presence of RPD. RESULTS: After controlling for age and axial length, the mean CT was significantly thinner in the GA group with RPD (213.7 +/- 53.1 mu m) than in the GA group without RPD (335.3 +/- 123.2 mu m; P =.001). The mean CT in the GA group without RPD was not statistically different from the mean CT in the normal control group (P = .076) or the drusen group without RPD (P = .45). In eyes without RPD, there was a correlation between the increasing size of GA and a decrease in CT measurements. CONCLUSION: Subfoveal choroidal thinning in eyes with nonexudative AMD was associated with the presence of RPD. In the absence of RPD, CT only decreased as the size of GA increased.
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