Journal
ONCOLOGY RESEARCH AND TREATMENT
Volume 38, Issue 6, Pages 311-315Publisher
KARGER
DOI: 10.1159/000431032
Keywords
Cadmium; Calcium homeostasis; Apoptosis; Autophagy; Tumorigenesis
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Funding
- Chinese National Natural Science Foundation [31271272, 31071030]
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Calcium and cadmium are divalent metals and have similar chemical properties. Both can enter cells through, albeit different, channels, or through protein-dependent permeation. However, cadmium disturbs the calcium homeostasis by inhibiting calcium channels and/or related proteins. Cadmium can also alter membrane phospholipid concentrations, and so induce a calcium homeostasis disorder. The altered calcium homeostasis induced by cadmium results in cell apoptosis, autophagy or tumorigenesis. In this review, calcium homeostasis disruption is summarized as a bridge connecting cadmium-induced apoptosis, autophagy, and tumorigenesis.
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