Journal
PLOS NEGLECTED TROPICAL DISEASES
Volume 4, Issue 9, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pntd.0000744
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Funding
- Medical Research Council, United Kingdom
- US National Institutes of Health [05TW006083, HHSN266200700022C, AI034238]
- MRC [MC_U117588500, MC_U190074190, MC_U190081982, MC_U190081991] Funding Source: UKRI
- Medical Research Council [MC_U190081982, MC_U190081991, MC_U190074190, MC_U117588500] Funding Source: researchfish
- FOGARTY INTERNATIONAL CENTER [K01TW006083] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI034238] Funding Source: NIH RePORTER
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Mycobacterium africanum consists of two phylogenetically distinct lineages within the Mycobacterium tuberculosis complex, known as M. africanum West African 1 and M. africanum West African 2. These lineages are restricted to West Africa, where they cause up to half of human pulmonary tuberculosis. In this review we discuss the definition of M. africanum, describe the prevalence and restricted geographical distribution of M. africanum West African 1 and 2, review the occurrence of M. africanum in animals, and summarize the phenotypic differences described thus far between M. africanum and M. tuberculosis sensu stricto.
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