Journal
NUCLEUS
Volume 6, Issue 1, Pages 19-22Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19491034.2014.1001705
Keywords
nucleoskeleton; nuclear lamins; emerin; nesprin; mechanotransduction
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Funding
- Agence National de la Recherche [ANR-13-JSV1-0008]
- European Union [304162]
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- National Institutes of Health [GM029860]
- Agence Nationale de la Recherche (ANR) [ANR-13-JSV1-0008] Funding Source: Agence Nationale de la Recherche (ANR)
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Cell phenotype and fate are driven by the mechanical properties of their surrounding environment. Changes in matrix rigidity or application of force have been shown to impact profoundly cell behavior and phenotype, demonstrating that the molecular mechanisms which sense and transduce these signals into biochemical pathways are central in cell biology. In this commentary, we discuss recent evidence showing that mechanotransduction mechanisms occur in the nucleus, allowing dynamic regulation of the nucleoskeleton in response to mechanical stress. We will review this nucleoskeletal response and its impact on both nuclear structure and function.
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