Journal
PLOS GENETICS
Volume 9, Issue 10, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.1003868
Keywords
-
Categories
Funding
- Wellcome Trust [098051, 086547]
- EU [HEALTH-F3-2009-223111 CAREPNEUMO]
- Swedish Research Council
- Stockholm County Council
- EU commission (PREVIS)
- Swedish Foundation for Strategic Research
- Knut and Alice Wallenberg foundation
- AXA Foundation
- Medical Research Council [MR/K010174/1B] Funding Source: researchfish
Ask authors/readers for more resources
Streptococcus pneumoniae of serotype 3 possess a mucoid capsule and cause disease associated with high mortality rates relative to other pneumococci. Phylogenetic analysis of a complete reference genome and 81 draft sequences from clonal complex 180, the predominant serotype 3 clone in much of the world, found most sampled isolates belonged to a clade affected by few diversifying recombinations. However, other isolates indicate significant genetic variation has accumulated over the clonal complex's entire history. Two closely related genomes, one from the blood and another from the cerebrospinal fluid, were obtained from a patient with meningitis. The pair differed in their behaviour in a mouse model of disease and in their susceptibility to antimicrobials, with at least some of these changes attributable to a mutation that up-regulated the patAB efflux pump. This indicates clinically important phenotypic variation can accumulate rapidly through small alterations to the genotype.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available