Journal
PLOS GENETICS
Volume 9, Issue 1, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.1003234
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Funding
- King's College London/The London Law Trust Medal Fellowship
- Wellcome Trust [085448/Z/08/Z]
- Medical Research Council [G1001689]
- MRC [G1001689] Funding Source: UKRI
- Wellcome Trust [085448/Z/08/Z] Funding Source: Wellcome Trust
- Medical Research Council [G1001689] Funding Source: researchfish
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What good are transposable elements (TEs)? Although their activity can be harmful to host genomes and can cause disease, they nevertheless represent an important source of genetic variation that has helped shape genomes. In this review, we examine the impact of TEs, collectively referred to as the mobilome, on the transcriptome. We explore how TEs-particularly retro-transposons-contribute to transcript diversity and consider their potential significance as a source of small RNAs that regulate host gene transcription. We also discuss a critical role for the mobilome in engineering transcriptional networks, permitting coordinated gene expression, and facilitating the evolution of novel physiological processes.
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