Journal
NEUROIMAGE-CLINICAL
Volume 9, Issue -, Pages 385-391Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2015.08.013
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Funding
- Human Frontier Science Program
- Wellcome Trust Biomedical research fellowship [WT093811MA]
- Human Frontier Science Program research grant
- Wellcome Trust [083660/Z/07/Z]
- Raymond and Beverly Sackler Studentship
- Cambridge Commonwealth Trust
- Stephen Erskine Fellowship
- British Oxygen Professorship of the Royal College of Anaesthetists
- Queens' College Cambridge
- National Research Council of Argentina (CONICET)
- Medical Research Council [G0001354B, G1000183B] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10090] Funding Source: researchfish
- Wellcome Trust [083660/Z/07/Z] Funding Source: Wellcome Trust
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Combining resting-state functional magnetic resonance imaging (fMRI) connectivity and behavioral analysis during sedation, we factored out general effects of the anesthetic drug propofol and a specific index of conscious report, participants' level of responsiveness. The factorial analysis shows that increasing concentration of propofol in blood specifically decreases the connectivity strength of fronto-parietal cortical loops. In contrast, loss of responsiveness is indexed by a functional disconnection between the thalamus and the frontal cortex, balanced by an increase in connectivity strength of the thalamus to the occipital and temporal regions of the cortex. (C) 2015 The Authors. Published by Elsevier Inc.
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