Journal
NEUROIMAGE-CLINICAL
Volume 7, Issue -, Pages 788-791Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2015.03.004
Keywords
Hippocampal sclerosis; T2 FLAIR; T2 mapping
Categories
Funding
- Wolfson Trust
- Epilepsy Society
- Department of Health's NIHR UCLH/UCL Biomedical Research Centre
- Health Innovation Challenge Fund [HICF-T4-275, WT097914]
- Wellcome Trust
- Department of Health
- National Institute for Health Research University College London Hospitals Biomedical Research Centre (NIHR BRC UCLH/UCL High Impact Initiative)
- National Institute for Health Research [NF-SI-0509-10161] Funding Source: researchfish
Ask authors/readers for more resources
Rationale: Qualitatively, FLAIR MR imaging is sensitive to the detection of hippocampal sclerosis (HS). Quantitative analysis of T2 maps provides a useful objective measure and increased sensitivity over visual inspection of T2-weighted scans. We aimed to determine whether quantification of normalised FLAIR is as sensitive as T2 mapping in detection of HS. Method: Dual echo T2 and FLAIR MR images were retrospectively analysed in 27 patients with histologically confirmed HS and increased T2 signal in ipsilateral hippocampus and 14 healthy controls. Regions of interest were manually segmented in all hippocampi aiming to avoid inclusion of CSF. Hippocampal T2 values and measures of normalised FLAIR Signal Intensity (nFSI) were compared in healthy and sclerotic hippocampi. Results: HS was identified on T2 values with 100% sensitivity and 100% specificity. HS was identified on nFSI measures with 60% sensitivity and 93% specificity. Conclusion: T2 mapping is superior to nFSI for identification of HS. (C) 2015 The Authors. Published by Elsevier Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available