Journal
PLOS GENETICS
Volume 4, Issue 7, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.1000118
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Funding
- National Heart Lung and Blood Institute
- National Cancer Institute (Bethesda, MD)
- Donald W Reynolds Foundation (Las Vegas, NV)
- Doris Duke Charitable Foundation
- Foundation Leducq (Paris, FR)
- Amgen, Inc
- Fonds de la Recherche en Sante du Quebec
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While circulating levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) have been associated with diverse conditions including myocardial infarction, stroke, malaria, and diabetes, comprehensive analysis of the common genetic determinants of sICAM-1 is not available. In a genome-wide association study conducted among 6,578 participants in the Women's Genome Health Study, we find that three SNPs at the ICAM1 (19p13.2) locus (rs1799969, rs5498 and rs281437) are non-redundantly associated with plasma sICAM-1 concentrations at a genome-wide significance level ( P, 5610 28), thus extending prior results from linkage and candidate gene studies. We also find that a single SNP (rs507666, P = 5.1610 229) at the ABO (9q34.2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes.
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