Journal
PLOS GENETICS
Volume 4, Issue 8, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.1000149
Keywords
-
Categories
Funding
- National Institute of Health [HL28481, DK071673, R01 DK072206, R01 MH71779, 1K25HL080079]
- NSF [0513612, 0731455]
Ask authors/readers for more resources
Quantitative trait locus (QTL) analysis is a powerful tool for mapping genes for complex traits in mice, but its utility is limited by poor resolution. A promising mapping approach is association analysis in outbred stocks or different inbred strains. As a proof of concept for the association approach, we applied whole-genome association analysis to hepatic gene expression traits in an outbred mouse population, the MF1 stock, and replicated expression QTL (eQTL) identified in previous studies of F2 intercross mice. We found that the mapping resolution of these eQTL was significantly greater in the outbred population. Through an example, we also showed how this precise mapping can be used to resolve previously identified loci (in intercross studies), which affect many different transcript levels (known as eQTL hotspots''), into distinct regions. Our results also highlight the importance of correcting for population structure in whole-genome association studies in the outbred stock.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available