Related references
Note: Only part of the references are listed.Thousands of chemical starting points for antimalarial lead identification
Francisco-Javier Gamo et al.
NATURE (2010)
Chemical genetics of Plasmodium falciparum
W. Armand Guiguemde et al.
NATURE (2010)
Modular architecture of nucleotide-binding pockets
Pier Federico Gherardini et al.
NUCLEIC ACIDS RESEARCH (2010)
A Multidimensional Strategy to Detect Polypharmacological Targets in the Absence of Structural and Sequence Homology
Jacob D. Durrant et al.
PLOS COMPUTATIONAL BIOLOGY (2010)
Protein Kinase G Is Required for Intrinsic Antibiotic Resistance in Mycobacteria
Kerstin A. Wolff et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
A unified statistical model to support local sequence order independent similarity searching for ligand-binding sites and its application to genome-based drug discovery
Lei Xie et al.
BIOINFORMATICS (2009)
Aligning Antimicrobial Drug Discovery with Complex and Redundant Host-Pathogen Interactions
Sarah L. Lebeis et al.
CELL HOST & MICROBE (2009)
Nothing about protein structure classification makes sense except in the light of evolution
Ruben E. Valas et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2009)
The topology of drug-target interaction networks: implicit dependence on drug properties and target families
Jordi Mestres et al.
MOLECULAR BIOSYSTEMS (2009)
Alignment-Free Prediction of a Drug-Target Complex Network Based on Parameters of Drug Connectivity and Protein Sequence of Receptors
Dolores Vina et al.
MOLECULAR PHARMACEUTICS (2009)
Predicting new molecular targets for known drugs
Michael J. Keiser et al.
NATURE (2009)
Protein promiscuity and its implications for biotechnology
Irene Nobeli et al.
NATURE BIOTECHNOLOGY (2009)
SYSTEMS MICROBIOLOGY - OPINION Drug interactions and the evolution of antibiotic resistance
Pamela J. Yeh et al.
NATURE REVIEWS MICROBIOLOGY (2009)
MODBASE, a database of annotated comparative protein structure models and associated resources
Ursula Pieper et al.
NUCLEIC ACIDS RESEARCH (2009)
A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore
J. Richard Miller et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Targeting a bacterial stress response to enhance antibiotic action
Samuel Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Drug Discovery Using Chemical Systems Biology: Repositioning the Safe Medicine Comtan to Treat Multi-Drug and Extensively Drug Resistant Tuberculosis
Sarah L. Kinnings et al.
PLOS COMPUTATIONAL BIOLOGY (2009)
Integrating Statistical Predictions and Experimental Verifications for Enhancing Protein-Chemical Interaction Predictions in Virtual Screening
Nobuyoshi Nagamine et al.
PLOS COMPUTATIONAL BIOLOGY (2009)
FINDSITELHM: A Threading-Based Approach to Ligand Homology Modeling
Michal Brylinski et al.
PLOS COMPUTATIONAL BIOLOGY (2009)
Drug Discovery Using Chemical Systems Biology: Identification of the Protein-Ligand Binding Network To Explain the Side Effects of CETP Inhibitors
Li Xie et al.
PLOS COMPUTATIONAL BIOLOGY (2009)
Mycobacterium tuberculosis Universal Stress Protein Rv2623 Regulates Bacillary Growth by ATP-Binding: Requirement for Establishing Chronic Persistent Infection
Joshua E. Drumm et al.
PLOS PATHOGENS (2009)
Inhibitors of Fabl, an enzyme drug target in the bacterial fatty acid biosynthesis pathway
Hao Lu et al.
ACCOUNTS OF CHEMICAL RESEARCH (2008)
1.9 Å structure of the signal receiver domain of the putative response regulator NarL from Mycobacterium tuberculosis
Robert Schnell et al.
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2008)
Prediction of drug-target interaction networks from the integration of chemical and genomic spaces
Yoshihiro Yamanishi et al.
BIOINFORMATICS (2008)
A ligand-based approach to mining the chemogenomic space of drugs
Elisabet Gregori-Puigjane et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2008)
Data completeness -: the Achilles heel of drug-target networks
Jordi Mestres et al.
NATURE BIOTECHNOLOGY (2008)
Network pharmacology: the next paradigm in drug discovery
Andrew L. Hopkins
NATURE CHEMICAL BIOLOGY (2008)
Genomic-scale prioritization of drug targets: the TDR Targets database
Fernan Agueero et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
Detecting evolutionary relationships across existing fold space, using sequence order-independent profile-profile alignments
Lei Xie et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr
Jennifer Baysarowich et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Targeting QseC signaling and virulence for antibiotic development
David A. Rasko et al.
SCIENCE (2008)
Drug target identification using side-effect similarity
Monica Campillos et al.
SCIENCE (2008)
DrugBank: a knowledgebase for drugs, drug actions and drug targets
David S. Wishart et al.
NUCLEIC ACIDS RESEARCH (2008)
In silico elucidation of the molecular mechanism defining the adverse effect of selective estrogen receptor modulators
Lei Xie et al.
PLOS COMPUTATIONAL BIOLOGY (2007)
Drug-target network
Muhammed A. Yildirim et al.
NATURE BIOTECHNOLOGY (2007)
eHiTS: A new fast, exhaustive flexible ligand docking system
Zsolt Zsoldos et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2007)
Investigating the metabolic capabilities of Mycobacterium tuberculosis H37Rv using the in silico strain iNJ661 and proposing alternative drug targets
Neema Jamshidi et al.
BMC SYSTEMS BIOLOGY (2007)
Structural and biophysical studies on two promoter recognition domains of the extra-cytoplasmic function cr factor from Mycobacterium tuberculosis
Krishan Gopal Thakur et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Relating protein pharmacology by ligand chemistry
Michael J. Keiser et al.
NATURE BIOTECHNOLOGY (2007)
Structure-based maximal affinity model predicts small-molecule druggability
Alan C. Cheng et al.
NATURE BIOTECHNOLOGY (2007)
GSMN-TB:: a web-based genome scale network model of Mycobacterium tuberculosis metabolism
Dany J. V. Beste et al.
GENOME BIOLOGY (2007)
Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox
Scott A. Becker et al.
NATURE PROTOCOLS (2007)
Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery
Hong-Fang Ji et al.
GENOME BIOLOGY (2007)
A robust and efficient algorithm for the shape description of protein structures and its application in predicting ligand binding sites
Lei Xie et al.
BMC BIOINFORMATICS (2007)
Mycobacterial shikimate pathway enzymes as targets for drug design
R. G. Ducati et al.
CURRENT DRUG TARGETS (2007)
Innovation - The Connectivity Map: a new tool for biomedical research
Justin Lamb
NATURE REVIEWS CANCER (2007)
Innovation - A robustness-based approach to systems-oriented drug design
Hiroaki Kitano
NATURE REVIEWS DRUG DISCOVERY (2007)
Characterization of a Mycobacterium tuberculosis mutant deficient in pH-sensing adenylate cyclase Rv1264
Dorothea Dittrich et al.
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2006)
Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis
Xin He et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease
Justin Lamb et al.
SCIENCE (2006)
Crystallization and preliminary X-ray crystallographic studies of Mycobacterium tuberculosis CRP/FNR family transcription regulator
Mohd Akif et al.
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2006)
Higher-order organization and regulation of adenylyl cyclases
Dermot M. F. Cooper et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2006)
Global mapping of pharmacological space
Gaia V. Paolini et al.
NATURE BIOTECHNOLOGY (2006)
Toward the structural genomics of complexes:: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis
Michael Strong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis
G Sulzenbacher et al.
EMBO JOURNAL (2006)
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae
NJ Krogan et al.
NATURE (2006)
Practical applications and feasibility of efflux pump inhibitors in the clinic - A vision for applied use
O Lomovskaya et al.
BIOCHEMICAL PHARMACOLOGY (2006)
Conformational diversity of ligands bound to proteins
GR Stockwell et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
DrugBank: a comprehensive resource for in silico drug discovery and exploration
David S. Wishart et al.
NUCLEIC ACIDS RESEARCH (2006)
Purification and characterization of a functionally active Mycobacterium tuberculosis pyrroline-5-carboxylate reductase
YP Yang et al.
PROTEIN EXPRESSION AND PURIFICATION (2006)
Structural basis of the drug-binding specificity of human serum albumin
J Ghuman et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages
J Rengarajan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
A member of the cAMP receptor protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of the rpfA gene coding for a resuscitation promoting factor
L Rickman et al.
MOLECULAR MICROBIOLOGY (2005)
Mycobacterium tuberculosis LprG (Rv1411c):: A novel TLR-2 ligand that inhibits human macrophage class II MHC antigen processing
AJ Gehring et al.
JOURNAL OF IMMUNOLOGY (2004)
Protein kinase G from pathogenic mycobacteria promotes survival within macrophages
A Walburger et al.
SCIENCE (2004)
Genetic requirements for mycobacterial survival during infection
CM Sassetti et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Preferential attachment in the protein network evolution
E Eisenberg et al.
PHYSICAL REVIEW LETTERS (2003)
Targeting tuberculosis and malaria through inhibition of enoyl reductase
MR Kuo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Genes required for mycobacterial growth defined by high density mutagenesis
CM Sassetti et al.
MOLECULAR MICROBIOLOGY (2003)
Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis
T Parish et al.
INFECTION AND IMMUNITY (2003)
The price of innovation: new estimates of drug development costs
JA DiMasi et al.
JOURNAL OF HEALTH ECONOMICS (2003)
Measuring preferential attachment in evolving networks
H Jeong et al.
EUROPHYSICS LETTERS (2003)
The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology
TC Terwilliger et al.
TUBERCULOSIS (2003)
Plasticity of enzyme active sites
AE Todd et al.
TRENDS IN BIOCHEMICAL SCIENCES (2002)
Adenylyl cyclase Rv1264 from Mycobacterium tuberculosis has an autoinhibitory N-terminal domain
JU Linder et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling
JC Betts et al.
MOLECULAR MICROBIOLOGY (2002)
The small world inside large metabolic networks
A Wagner et al.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2001)
Clustering and preferential attachment in growing networks
MEJ Newman
PHYSICAL REVIEW E (2001)
The large-scale organization of metabolic networks
H Jeong et al.
NATURE (2000)
The ATP binding cassette (ABC) transport systems of Mycobacterium tuberculosis
M Braibant et al.
FEMS MICROBIOLOGY REVIEWS (2000)
The Protein Data Bank
HM Berman et al.
NUCLEIC ACIDS RESEARCH (2000)
Share Paper
