Related references
Note: Only part of the references are listed.The control systems structures of energy metabolism
Mathieu Cloutier et al.
JOURNAL OF THE ROYAL SOCIETY INTERFACE (2010)
Metformin Induces a Dietary Restriction-Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
Brian Onken et al.
PLOS ONE (2010)
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
Angela Alexander et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease
Gerasimos P. Sykiotis et al.
SCIENCE SIGNALING (2010)
Lingering prenatal effects of the 1918 influenza pandemic on cardiovascular disease
B. Mazumder et al.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2010)
Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae
Ashley L. Alvers et al.
AGING CELL (2009)
SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span
Tiara L. A. Kawahara et al.
CELL (2009)
Atypical pathways of NF-κB activation and aging
Andres Kriete et al.
EXPERIMENTAL GERONTOLOGY (2009)
Toward a Systems Biology Framework for Understanding Aging and Health Span
Geoffrey B. West et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2009)
Expression and mechanism of mammalian target of rapamycin in age-related renal cell senescence and organ aging
Li Zhuo et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2009)
JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy
Hai Wu et al.
MECHANISMS OF DEVELOPMENT (2009)
Direct control of mitochondrial function by mTOR
Arvind Ramanathan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Internal coarse-graining of molecular systems
Jerome Feret et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
Anat Ben-Zvi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1
Sandy D. Westerheide et al.
SCIENCE (2009)
Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia
Emanuela Santini et al.
SCIENCE SIGNALING (2009)
Obesity Increases Vascular Senescence and Susceptibility to Ischemic Injury Through Chronic Activation of Akt and mTOR
Chao-Yung Wang et al.
SCIENCE SIGNALING (2009)
Fuzzy Logic Analysis of Kinase Pathway Crosstalk in TNF/EGF/Insulin-Induced Signaling
Bree B. Aldridge et al.
PLOS COMPUTATIONAL BIOLOGY (2009)
A Regulated Response to Impaired Respiration Slows Behavioral Rates and Increases Lifespan in Caenorhabditis elegans
David Cristina et al.
PLOS GENETICS (2009)
Human models of aging and longevity
E. Cevenini et al.
EXPERT OPINION ON BIOLOGICAL THERAPY (2008)
Akt-dependent regulation of NF-κB is controlled by mTOR and Raptor in association with IKK
Han C. Dan et al.
GENES & DEVELOPMENT (2008)
Repression of gene expression by unphosphorylated NF-κB p65 through epigenetic mechanisms
Jie Dong et al.
GENES & DEVELOPMENT (2008)
Quantitative evidence for conserved longevity pathways between divergent eukaryotic species
Erica D. Smith et al.
GENOME RESEARCH (2008)
A distinctive physiological role for IκBβ in the propagation of mitochondrial respiratory stress signaling
Gopa Biswas et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
mTOR-dependent signalling in Alzheimer's disease
Jin-Jing Pei et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2008)
A methodology for performing global uncertainty and sensitivity analysis in systems biology
Simeone Marino et al.
JOURNAL OF THEORETICAL BIOLOGY (2008)
Aging-induced alterations in gene transcripts and functional activity of mitochondrial oxidative phosphorylation complexes in the heart
Claudia C. Preston et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2008)
Feedback loops shape cellular signals in space and time
Onn Brandman et al.
SCIENCE (2008)
Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity
Andres Kriete et al.
Immunity & Ageing (2008)
Motif module map reveals enforcement of aging by continual NF-κB activity
Adam S. Adler et al.
GENES & DEVELOPMENT (2007)
mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex
John T. Cunningham et al.
NATURE (2007)
AGEMAP: A gene expression database for aging in mice
Jacob M. Zahn et al.
PLOS GENETICS (2007)
Mitchondrial dysfunction and age
Kevin E. Conley et al.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2007)
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
D. Grahame Hardie
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Long-term effects of increased glucose entry on mouse hearts during normal aging and ischemic stress
Ivan Luptak et al.
CIRCULATION (2007)
Buffering mechanisms in aging: A systems approach toward uncovering the genetic component of aging
Aviv Bergman et al.
PLOS COMPUTATIONAL BIOLOGY (2007)
Autophagy, mitochondria and cell death in lysosomal storage diseases
Kirill Kiselyov et al.
AUTOPHAGY (2007)
Mitochondrial function, fibre types and ageing:: new insights from human muscle in vivo
Kevin E. Conley et al.
EXPERIMENTAL PHYSIOLOGY (2007)
Systems biology by the rules: hybrid intelligent systems for pathway modeling and discovery
William J. Bosl
BMC SYSTEMS BIOLOGY (2007)
The mitochondrial energy transduction system and the aging process
Ana Navarro et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)
The role of nuclear architecture in genomic instability and ageing
Philipp Oberdoerffer et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Dose response relationship in anti-stress gene regulatory networks
Qiang Zhang et al.
PLOS COMPUTATIONAL BIOLOGY (2007)
Application of Petri net based analysis techniques to signal transduction pathways
Andrea Sackmann et al.
BMC BIOINFORMATICS (2006)
Oxidative phosphorylation and aging
Edward J. Lesnefsky et al.
AGEING RESEARCH REVIEWS (2006)
Systems approaches to the networks of aging
Andres Kriete et al.
AGEING RESEARCH REVIEWS (2006)
Data-driven modelling of signal-transduction networks
Kevin A. Janes et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
Linking data to models: data regression
Khuloud Jaqaman et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour
B. B. Aldridge et al.
IEE PROCEEDINGS SYSTEMS BIOLOGY (2006)
Physicochemical modelling of cell signalling pathways
Bree B. Aldridge et al.
NATURE CELL BIOLOGY (2006)
The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
Stefan M. Schieke et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-κB activation and cell survival
Sourav Ghosh et al.
CANCER CELL (2006)
Redox regulatory mechanisms in cellular stress responses
Nina Fedoroff
ANNALS OF BOTANY (2006)
Transcriptional profiling of aging in human muscle reveals a common aging signature
Jacob M. Zahn et al.
PLOS GENETICS (2006)
Testing the vicious cycle theory of mitochondrial ROS production:: effects of H2O2 and cumene hydroperoxide treatment on heart mitochondria
Alberto Sanz et al.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2006)
Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis
N Miyoshi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Infection, inflammation, height, and longevity
EM Crimmins et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Age-related neural degeneration in nuclear-factor kappa B P50 knockout mice
Z. -Y. Lu et al.
NEUROSCIENCE (2006)
Mathematical approaches to differentiation and gene regulation
C Soule
COMPTES RENDUS BIOLOGIES (2006)
Cells discover fire: Employing reactive oxygen species in development and consequences for aging
JP de Magalhaes et al.
EXPERIMENTAL GERONTOLOGY (2006)
Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production
A Trifunovic et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscle
DJ Marcinek et al.
JOURNAL OF PHYSIOLOGY-LONDON (2005)
Modeling gene expression networks using fuzzy logic
P Du et al.
IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS PART B-CYBERNETICS (2005)
Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex
DD Sarbassov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
FOXO transcription factors at the interface between longevity and tumor suppression
EL Greer et al.
ONCOGENE (2005)
On the relevance of mitochondrial fusions for the accumulation of mitochondrial deletion mutants: A modelling study
A Kowald et al.
AGING CELL (2005)
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
GC Kujoth et al.
SCIENCE (2005)
Iterative approach to model identification of biological networks
KG Gadkar et al.
BMC BIOINFORMATICS (2005)
In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans
B Gerstbrein et al.
AGING CELL (2005)
Pathway-specific profiling identifies the NF-κB-dependent tumor necrosis factor α-regulated genes in epidermal keratinocytes
T Banno et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Causal protein-signaling networks derived from multiparameter single-cell data
K Sachs et al.
SCIENCE (2005)
Sensitivity analysis of discrete stochastic systems
R Gunawan et al.
BIOPHYSICAL JOURNAL (2005)
Mitochondria, oxidants, and aging
RS Balaban et al.
CELL (2005)
Common and cell type-specific responses of human cells to mitochondrial dysfunction
MV Miceli et al.
EXPERIMENTAL CELL RESEARCH (2005)
Modelling the actions of chaperones and their role in ageing
CJ Proctor et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2005)
Aging elevates basal adenosine monophosphate-activated protein kinase (AMPK) activity and eliminates hypoxic activation of AMPK in mouse liver
JD Mulligan et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2005)
Mitochondrial signaling: The retrograde response
RA Butow et al.
MOLECULAR CELL (2004)
Inferring cellular networks using probabilistic graphical models
N Friedman
SCIENCE (2004)
Nuclear factor kappa B activation by NADPH oxidases
RA Clark et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2004)
Linear fuzzy gene network models obtained from microarray data by exhaustive search
BA Sokhansanj et al.
BMC BIOINFORMATICS (2004)
Oxidative DNA damage background estimated by a system model of base excision repair
BA Sokhansanj et al.
FREE RADICAL BIOLOGY AND MEDICINE (2004)
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C-elegans
J Apfeld et al.
GENES & DEVELOPMENT (2004)
Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease
T Grune et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)
Gene regulation and DNA damage in the ageing human brain
T Lu et al.
NATURE (2004)
Dual role of oxidized LDL on the NF-KappaB signaling pathway
F Robbesyn et al.
FREE RADICAL RESEARCH (2004)
Gene expression profile of aging in human muscle
S Welle et al.
PHYSIOLOGICAL GENOMICS (2003)
Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell
JJ Tyson et al.
CURRENT OPINION IN CELL BIOLOGY (2003)
Rapamycin attenuates load-induced cardiac hypertrophy in mice
T Shioi et al.
CIRCULATION (2003)
Oxidant signals and oxidative stress
T Finkel
CURRENT OPINION IN CELL BIOLOGY (2003)
Towards an e-biology of ageing: integrating theory and data
TBL Kirkwood et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)
NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia
M Dajee et al.
NATURE (2003)
NF-κB and IκBα are found in the mitochondria -: Evidence for regulation of mitochondrial gene expression by NF-κB
PC Cogswell et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Rule-base derivation for intensive care ventilator control using ANFIS
HF Kwok et al.
ARTIFICIAL INTELLIGENCE IN MEDICINE (2003)
c-Myc exerts a protective function through ornithine decarboxylase against cellular insults
JK Park et al.
MOLECULAR PHARMACOLOGY (2002)
Stochastic and genetic factors influence tissue-specific decline in ageing C-elegans
LA Herndon et al.
NATURE (2002)
Decreased glycolytic metabolism contributes to but is not the inducer of apoptosis following IL-3-starvation
S Gonin-Giraud et al.
CELL DEATH AND DIFFERENTIATION (2002)
Does p53 affect organismal aging?
LA Donehower
JOURNAL OF CELLULAR PHYSIOLOGY (2002)
Impacts of transcriptional regulation on aging and senescence
AK Roy et al.
AGEING RESEARCH REVIEWS (2002)
AMP-activated kinase regulates cytoplasmic HuR
W Wang et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Allometric scaling of metabolic rate from molecules and mitochondria to cells and mammals
GB West et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain
MT Lin et al.
HUMAN MOLECULAR GENETICS (2002)
Superoxide activates mitochondrial uncoupling proteins
KS Echtay et al.
NATURE (2002)
Modeling and simulation of genetic regulatory systems: A literature review
H De Jong
JOURNAL OF COMPUTATIONAL BIOLOGY (2002)
Explaining mortality rate plateaus
JS Weitz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
AMP-activated protein kinase: the energy charge hypothesis revisited
DG Hardie et al.
BIOESSAYS (2001)
Rate-adaptive pacemaker controlled by motion and respiratory rate using neuro-fuzzy algorithm
JW Shin et al.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING (2001)
Mathematical modeling of the aging processes and the mechanisms of mortality: paramount role of heterogeneity
G Rossolini et al.
EXPERIMENTAL GERONTOLOGY (2001)
Decreased Pasteur effect in platelets of aged individuals
M D'Aurelio et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2001)
Aging and proinflammatory cytokines
H Bruunsgaard et al.
CURRENT OPINION IN HEMATOLOGY (2001)
Kinetics of human aging: I. Rates of senescence between ages 30 and 70 years in healthy people
ME Sehl et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2001)
Lipofuscin accumulation in proliferating fibroblasts in vitro: an indicator of oxidative stress
N Sitte et al.
EXPERIMENTAL GERONTOLOGY (2001)
Oxidants, oxidative stress and the biology of ageing
T Finkel et al.
NATURE (2000)
Genetic pathways that regulate ageing in model organisms
L Guarente et al.
NATURE (2000)
Tor-mediated induction of autophagy via an Apg1 protein kinase complex
Y Kamada et al.
JOURNAL OF CELL BIOLOGY (2000)
Interaction of the receptor for advanced glycation end products (RAGE) with transthyretin triggers nuclear transcription factor kB (NF-kB) activation
MM Sousa et al.
LABORATORY INVESTIGATION (2000)
Accumulation of defective mitochondria through delayed degradation of damaged organelles and its possible role in the ageing of post-mitotic and dividing cells
A Kowald et al.
JOURNAL OF THEORETICAL BIOLOGY (2000)