Related references
Note: Only part of the references are listed.A unified statistical model to support local sequence order independent similarity searching for ligand-binding sites and its application to genome-based drug discovery
Lei Xie et al.
BIOINFORMATICS (2009)
Drug Discovery Using Chemical Systems Biology: Identification of the Protein-Ligand Binding Network To Explain the Side Effects of CETP Inhibitors
Li Xie et al.
PLOS COMPUTATIONAL BIOLOGY (2009)
Discovery of drug-like inhibitors of an essential RNA-editing ligase in Trypanosoma brucei
Rommie E. Amaro et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Detecting evolutionary relationships across existing fold space, using sequence order-independent profile-profile alignments
Lei Xie et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
In silico elucidation of the molecular mechanism defining the adverse effect of selective estrogen receptor modulators
Lei Xie et al.
PLOS COMPUTATIONAL BIOLOGY (2007)
A high-throughput screen for aggregation-based inhibition in a large compound library
Brian Y. Feng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Relating protein pharmacology by ligand chemistry
Michael J. Keiser et al.
NATURE BIOTECHNOLOGY (2007)
A robust and efficient algorithm for the shape description of protein structures and its application in predicting ligand binding sites
Lei Xie et al.
BMC BIOINFORMATICS (2007)
Travel depth, a new shape descriptor for macromolecules: Application to ligand binding
Ryan G. Coleman et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Global mapping of pharmacological space
Gaia V. Paolini et al.
NATURE BIOTECHNOLOGY (2006)
On the nature of cavities on protein surfaces: Application to the identification of drug-binding sites
Murad Nayal et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2006)
Estimating the cost of new drug development: Is it really $802 million?
CP Adams et al.
HEALTH AFFAIRS (2006)
An intuitive approach to measuring protein surface curvature
RG Coleman et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2005)
Public-private partnership: from there to here
SL Croft
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE (2005)
Predicting protein function from sequence and structural data
JD Watson et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2005)
Kinomics-structural biology and chemogenomics of kinase inhibitors and targets
M Vieth et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2004)
Structural rearrangement accompanying NAD+ synthesis within a bacterial DNA ligase crystal
KS Gajiwala et al.
STRUCTURE (2004)
Enzyme classification by ligand binding
S Izrailev et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2004)
Human DNA ligase I completely encircles and partially unwinds nicked DNA
JM Pascal et al.
NATURE (2004)
The Catalytic Site Atlas: a resource of catalytic sites and residues identified in enzymes using structural data
CT Porter et al.
NUCLEIC ACIDS RESEARCH (2004)
Characterization of 2-enoyl thioester reductase from mammals -: An ortholog of Ybr026p/Mrf1′p of the yeast mitochondrial fatty acid synthesis type II
IJ Miinalainen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
High-resolution crystal structure of Trypanosoma brucei UDP-galactose 4′-epimerase:: a potential target for structure-based development of novel trypanocides
MP Shaw et al.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2003)
Galactose metabolism is essential for the African sleeping sickness parasite Trypanosoma brucei
JR Roper et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
The crystal structure of dTDP-D-glucose 4,6-dehydratase (RmlB) from Salmonella enterica serovar typhimurium, the second enzyme in the dTDP-L-rhamnose pathway
STM Allard et al.
JOURNAL OF MOLECULAR BIOLOGY (2001)
An RNA ligase essential for RNA editing and survival of the bloodstream form of Trypanosoma brucei
A Schnaufer et al.
SCIENCE (2001)
The two RNA ligases of the Trypanosoma brucei RNA editing complex:: Cloning the essential band IV gene and identifying the band V gene
LN Rusché et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG
AY Lau et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
The Protein Data Bank
HM Berman et al.
NUCLEIC ACIDS RESEARCH (2000)
Share Paper
