Related references
Note: Only part of the references are listed.Predicting Protein Function and Binding Profile via Matching of Local Evolutionary and Geometric Surface Patterns
Yan Yuan Tseng et al.
JOURNAL OF MOLECULAR BIOLOGY (2009)
The failure of torcetrapib: What have we learned?
T. R. Joy et al.
BRITISH JOURNAL OF PHARMACOLOGY (2008)
Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone
M. J. Forrest et al.
BRITISH JOURNAL OF PHARMACOLOGY (2008)
Endothelial S100A1 modulates vascular function via nitric oxide
Sven T. Pleger et al.
CIRCULATION RESEARCH (2008)
Large-scale prediction of drug-target relationships
Michael Kuhn et al.
FEBS LETTERS (2008)
Nuclear hormone receptors as regulators of the renin-angiotensin-aldosterone system
Irma Kuipers et al.
HYPERTENSION (2008)
Quantifying the relationships among drug classes
Jerome Hert et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2008)
Hemoglobin Is Expressed by Mesangial Cells and Reduces Oxidant Stress
Hiroshi Nishi et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2008)
Integration of metabolism and inflammation by lipid-activated nuclear receptors
Steven J. Bensinger et al.
NATURE (2008)
Pseudoreceptor models in drug design: bridging ligand- and receptor-based virtual screening
Yusuf Tanrikulu et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets
Masato Furuhashi et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
Detecting evolutionary relationships across existing fold space, using sequence order-independent profile-profile alignments
Lei Xie et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Drug target identification using side-effect similarity
Monica Campillos et al.
SCIENCE (2008)
chemogenomics and biotechnology
Arthur Wuster et al.
TRENDS IN BIOTECHNOLOGY (2008)
Spotlight on HDL-raising therapies:: insights from the torcetrapib trials
Anatol Kontush et al.
NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE (2008)
FunSimMat: a comprehensive functional similarity database
Andreas Schlicker et al.
NUCLEIC ACIDS RESEARCH (2008)
The Pfam protein families database
Robert D. Finn et al.
NUCLEIC ACIDS RESEARCH (2008)
Effects of torcetrapib in patients at high risk for coronary events
Philip J. Barter et al.
NEW ENGLAND JOURNAL OF MEDICINE (2007)
In silico elucidation of the molecular mechanism defining the adverse effect of selective estrogen receptor modulators
Lei Xie et al.
PLOS COMPUTATIONAL BIOLOGY (2007)
Ubiquinol-cytochrome-c reductase 7.2 kDa protein of mitochondrial complex III is steroid-responsive and increases in cardiac hypertrophy and hypertension
Hung Huynh et al.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2007)
eHiTS: A new fast, exhaustive flexible ligand docking system
Zsolt Zsoldos et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2007)
iHOP web services
Jose M. Fernandez et al.
NUCLEIC ACIDS RESEARCH (2007)
Macrophage-specific PPARγ controls alternative activation and improves insulin resistance
Justin I. Odegaard et al.
NATURE (2007)
Peroxisomal proliferator-activated receptor-α-dependent inhibition of endothelial cell proliferation and tumorigenesis
Ambra Pozzi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Surflex-Dock 2.1: Robust performance from ligand energetic modeling, ring flexibility, and knowledge-based search
Ajay N. Jain
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2007)
The transcription factor nuclear factor-kappa B and cancer
R. O. Escarcega et al.
CLINICAL ONCOLOGY (2007)
Relating protein pharmacology by ligand chemistry
Michael J. Keiser et al.
NATURE BIOTECHNOLOGY (2007)
Chemogenomic data analysis: Prediction of small-molecule targets and the advent of biological fingerprints
Andreas Bender et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2007)
Chemogenomic approaches to rational drug design
D. Rognan
BRITISH JOURNAL OF PHARMACOLOGY (2007)
A robust and efficient algorithm for the shape description of protein structures and its application in predicting ligand binding sites
Lei Xie et al.
BMC BIOINFORMATICS (2007)
Multi-target therapeutics: when the whole is greater than the sum of the parts
Grant R. Zimmermann et al.
DRUG DISCOVERY TODAY (2007)
Generalized modeling of enzyme-ligand interactions using proteochemometrics and local protein substructures
Helena Strombergsson et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2006)
A critical assessment of docking programs and scoring functions
Gregory L. Warren et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Systems biology and combination therapy in the quest for clinical efficacy
Jonathan B. Fitzgerald et al.
NATURE CHEMICAL BIOLOGY (2006)
Global mapping of pharmacological space
Gaia V. Paolini et al.
NATURE BIOTECHNOLOGY (2006)
CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues
Joe Dundas et al.
NUCLEIC ACIDS RESEARCH (2006)
From the similarity analysis of protein cavities to the functional classification of protein families using Cavbase
Daniel Kuhn et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens
EM Sternberg
NATURE REVIEWS IMMUNOLOGY (2006)
A virtual active compound produced from the negative image of a ligand-binding pocket, and its application to in-silico drug screening
Yoshifumi Fukunishi et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2006)
A searchable database for comparing protein-ligand binding sites for the analysis of structure-function relationships
ND Gold et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2006)
Nuclear factor-κB affects tumor progression in a mouse model of malignant pleural effusion
GT Stathopoulos et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2006)
Can we rationally design promiscuous drugs?
AL Hopkins et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2006)
Cross-talk between IGF-I and TGF-β signaling pathways
D Danielpour et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2006)
SitesBase: a database for structure-based protein-ligand binding site comparisons
Nicola D. Gold et al.
NUCLEIC ACIDS RESEARCH (2006)
Oxidative metabolism and PGC-1 beta attenuate macrophage-mediated inflammation
Divya Vats et al.
CELL METABOLISM (2006)
Finding new tricks for old drugs: An efficient route for public-sector drug discovery
KA O'Connor et al.
NATURE REVIEWS DRUG DISCOVERY (2005)
JTT-705 blocks cell proliferation and angiogenesis through p38 kinase/p27kip1 and Ras/p21waf1 pathways
S Miura et al.
ATHEROSCLEROSIS (2005)
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ
G Pascual et al.
NATURE (2005)
Protein function prediction using local 3D templates
RA Laskowski et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
Functional coverage of the human genome by existing structures, structural genomics targets, and homology models
L Xie et al.
PLOS COMPUTATIONAL BIOLOGY (2005)
Predicting protein function from sequence and structural data
JD Watson et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2005)
ZINC - A free database of commercially available compounds for virtual screening
JJ Irwin et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2005)
Membrane lipids and cell death: an overview
IM Cristea et al.
CHEMISTRY AND PHYSICS OF LIPIDS (2004)
Expression of HbC and HbS, but not HbA, results in activation of K-Cl cotransport activity in transgenic mouse red cells
JR Romero et al.
BLOOD (2004)
Biological functions of phosphatidylinositol transfer proteins
SM Routt et al.
BIOCHEMISTRY AND CELL BIOLOGY (2004)
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: New pharmacological opportunities due to related binding site recognition
A Weber et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Functional analysis of peroxisome-proliferator-responsive element motifs in genes of fatty acid-binding proteins
C Schachtrup et al.
BIOCHEMICAL JOURNAL (2004)
Exploring the chemogenomic knowledge space with annotated chemical libraries
NP Savchuk et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2004)
Drug repositioning: Identifying and developing new uses for existing drugs
TT Ashburn et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
Efficient similarity search in protein structure databases by k-clique hashing
N Weskamp et al.
BIOINFORMATICS (2004)
pvSOAR: detecting similar surface patterns of pocket and void surfaces of amino acid residues on proteins
TA Binkowski et al.
NUCLEIC ACIDS RESEARCH (2004)
Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host
W Khovidhunkit et al.
JOURNAL OF LIPID RESEARCH (2004)
PDBSiteScan: a program for searching for active, binding and posttranslational modification sites in the 3D structures of proteins
VA Ivanisenko et al.
NUCLEIC ACIDS RESEARCH (2004)
Recognition of functional sites in protein structures
A Shulman-Peleg et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Assessing scoring functions for protein-ligand interactions
P Ferrara et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Strategies for multiple signalling inhibition
G Tortora et al.
JOURNAL OF CHEMOTHERAPY (2004)
Dependence of peroxisome proliferator-activated receptor ligand-induced mitogen-activated protein kinase signaling on epidermal growth factor receptor transactivation
OS Gardner et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Inferring functional relationships of proteins from local sequence and spatial surface patterns
TA Binkowski et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Identification of protein biochemical functions by similarity search using the molecular surface database eF-site
K Kinoshita et al.
PROTEIN SCIENCE (2003)
A new bioinformatic approach to detect common 3D sites in protein structures
M Jambon et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2003)
Comparative evaluation of 11 scoring functions for molecular docking
RX Wang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Lipids and the immune response: from molecular mechanisms to clinical applications
P Yaqoob
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2003)
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
SB Joseph et al.
NATURE MEDICINE (2003)
A new method to detect related function among proteins independent of sequence and fold homology
S Schmitt et al.
JOURNAL OF MOLECULAR BIOLOGY (2002)
Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription
NS Tan et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
The role of calcium-binding proteins in the control of transcription: structure to function
M Ikura et al.
BIOESSAYS (2002)
AP-1-glucocorticoid receptor crosstalk taken to a higher level
M Karin et al.
JOURNAL OF ENDOCRINOLOGY (2001)
Mammalian MAP kinase signalling cascades
LF Chang et al.
NATURE (2001)
Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors α- and γ-mediated gene expression via liver fatty acid binding protein:: A signaling path to the nucleus
C Wolfrum et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
K : Cl cotransport activity is inhibited by HCO3- in knockout mouse red cells expressing human HbC
JR Romero et al.
BLOOD CELLS MOLECULES AND DISEASES (2001)
Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-γ and nuclear factor-κB
SW Chung et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
The glucocorticoid receptor inhibits NFκB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain
RM Nissen et al.
GENES & DEVELOPMENT (2000)
Peroxisome proliferator-activated receptor γ-dependent repression of the inducible nitric oxide synthase gene
M Li et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
The Protein Data Bank
HM Berman et al.
NUCLEIC ACIDS RESEARCH (2000)
Share Paper
