Journal
PLOS BIOLOGY
Volume 12, Issue 9, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.1001944
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Funding
- 973 Program [2011CBA00400]
- National Natural Science Foundation of China Project [31025012]
- Hundreds of Talents Program from Chinese Academy of Sciences
- PICS-NavROLE
- European Union [602531 DESIRE'']
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Action potential (AP) generation in inhibitory interneurons is critical for cortical excitation-inhibition balance and information processing. However, it remains unclear what determines AP initiation in different interneurons. We focused on two predominant interneuron types in neocortex: parvalbumin (PV)-and somatostatin (SST)-expressing neurons. Patch-clamp recording from mouse prefrontal cortical slices showed that axonal but not somatic Na+ channels exhibit different voltage-dependent properties. The minimal activation voltage of axonal channels in SST was substantially higher (similar to 7mV) than in PV cells, consistent with differences in AP thresholds. A more mixed distribution of high-and low-threshold channel subtypes at the axon initial segment (AIS) of SST cells may lead to these differences. Surprisingly, Na(V)1.2 was found accumulated at AIS of SST but not PV cells; reducing Na(V)1.2-mediated currents in interneurons promoted recurrent network activity. Together, our results reveal the molecular identity of axonal Na+ channels in interneurons and their contribution to AP generation and regulation of network activity.
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