Journal
PLOS BIOLOGY
Volume 11, Issue 10, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.1001672
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Funding
- Agence Nationale de la Recherche (ANR) [ANR-08-JCJC-0134 RCS, ANR-12-JSV3-0001, ANR-10-INBS-04-01]
- NIH [R01 DK 57731]
- Agence Nationale de la Recherche (ANR) [ANR-08-JCJC-0134, ANR-12-JSV3-0001] Funding Source: Agence Nationale de la Recherche (ANR)
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Lymph node (LN) stromal cells provide survival signals and adhesive substrata to lymphocytes. During an immune response, B cell follicles enlarge, questioning how LN stromal cells manage these cellular demands. Herein, we used a murine fate mapping system to describe a new stromal cell type that resides in the T cell zone of resting LNs. We demonstrated that upon inflammation, B cell follicles progressively trespassed into the adjacent T cell zone and surrounded and converted these stromal cells into CXCL13 secreting cells that in return delineated the new boundaries of the growing follicle. Acute B cell ablation in inflamed LNs abolished CXCL13 secretion in these cells, while LT-beta deficiency in B cells drastically affected this conversion. Altogether, we reveal the existence of a dormant stromal cell subset that can be functionally awakened by B cells to delineate the transient boundaries of their expanding territories upon inflammation.
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