Journal
PLOS BIOLOGY
Volume 6, Issue 10, Pages 2329-2342Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.0060252
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Funding
- Telethon fellowships
- Fondazione Telethon [TCP03009]
- Giovanni Armenise Harvard Foundation
- MIUR [RBIN04N4KB]
- HFSP [CDA026/2004]
- National Institutes of Health [GM077452]
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ATP-dependent nucleosome-remodeling enzymes and covalent modifiers of chromatin set the functional state of chromatin. However, how these enzymatic activities are coordinated in the nucleus is largely unknown. We found that the evolutionary conserved nucleosome-remodeling ATPase ISWI and the poly-ADP-ribose polymerase PARP genetically interact. We present evidence showing that ISWI is target of poly-ADP-ribosylation. Poly-ADP-ribosylation counteracts ISWI function in vitro and in vivo. Our work suggests that ISWI is a physiological target of PARP and that poly-ADP-ribosylation can be a new, important post-translational modification regulating the activity of ATP-dependent nucleosome remodelers.
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