Journal
PLOS BIOLOGY
Volume 6, Issue 2, Pages 240-252Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.0060017
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Funding
- NICHD NIH HHS [R01 HD039899, HD-039899] Funding Source: Medline
- NINDS NIH HHS [R01 NS052842, NS052842] Funding Source: Medline
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Amyloids are highly organized protein aggregates that are associated with both neurodegenerative diseases such as Alzheimer disease and benign functions like skin pigmentation. Amyloids self-polymerize in a nucleation-dependent manner by recruiting their soluble protein/peptide counterpart and are stable against harsh physical, chemical, and biochemical conditions. These extraordinary properties make amyloids attractive for applications in nanotechnology. Here, we suggest the use of amyloids in the formulation of long-acting drugs. It is our rationale that amyloids have the properties required of a long-acting drug because they are stable depots that guarantee a controlled release of the active peptide drug from the amyloid termini. This concept is tested with a family of short-and long-acting analogs of gonadotropin-releasing hormone ( GnRH), and it is shown that amyloids thereof can act as a source for the sustained release of biologically active peptides.
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