Journal
MATERIALS HORIZONS
Volume 2, Issue 1, Pages 100-105Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4mh00164h
Keywords
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Funding
- Singapore National Research Foundation [R-279-000- 390-281]
- Singapore-MIT Alliance for Research and Technology (SMART) Innovation [R279-000-378-592]
- Institute of Materials Research and Engineering of A-Star, Singapore [IMRE/14-8P1110]
- National University of Singapore [R279-000-415-112]
- Research Grants Council of Hong Kong [HKUST2/CRF/10, N_HKUST620/11]
- Guangdong Innovative Research Team Program of China [20110C0105067115]
- NSFC [81301311]
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A pH-responsive light-up nanoparticle probe with aggregation-induced emission (AIE) features was designed and synthesized. The probe carries negative charges and shows very weak fluorescence under physiological conditions. In a tumor acidic extracellular micro-environment, the nanoparticle probe can switch to positive surface charge and thus significantly light up cancer cells, allowing for targeted imaging and selective suppression of cancer cells. As AIE nanoparticles are known for high fluorescence in the aggregate state, this study represents the first example of light-up AIE nanoparticle probe design.
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