Journal
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
Volume 115, Issue 4, Pages 505-514Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.oooo.2012.11.004
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Funding
- National Cancer Institute [CA78527]
- National Institute for Dental and Craniofacial Research [DE021671]
- Einstein-Montefiore Center for AIDS
- National Institutes of Health [AI051519]
- Einstein Cancer Research Center [P30-CA013330]
- National Cancer Institute
- New Jersey Dental School Department of Diagnostic Sciences
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Objective. To evaluate reproducibility of oral rinse self-collection for human papillomavirus (HPV) detection and investigate associations between oral HPV, oral lesions, immune and sociodemographic factors, we performed a cross-sectional study of older adults with human immunodeficiency virus (HIV) infection. Study Design. We collected oral rinse samples from 52 subjects at 2 different times of day, followed by an oral examination and interview. We identified HPV with the use of polymerase chain reaction platforms optimized for detection of mucosal and cutaneous types. Results. Eighty-seven percent of individuals had oral HPV, of which 23% had oncogenic alpha, 40% had nononcogenic alpha, and 46% had beta or gamma HPV. Paired oral specimens were concordant in all parameters tested. Significant associations observed for oral HPV with increased HIV viral load, hepatitis C seropositivity, history of sexually transmitted diseases, and lifetime number of sexual partners. Conclusions. Oral cavity may be a reservoir of subclinical HPV in older adults who have HIV infection. Understanding natural history, transmission, and potential implications of oral HPV warrants further investigations. (Oral Surg Oral Med Oral Pathol Oral Radiol 2013;115:505-514)
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