The Synthesis of N-Substituted N,S-Macroheterocycles Derived from Aromatic Carboxylic Acid Hydrazides

A selective catalytic cyclothiomethylation method for the synthesis of N, S-macroheterocycles having N-amide substituents is elaborated via the reaction between aromatic carboxylic acid hydrazides, formaldehyde, and alpha,omega-dithiols possessing from 4 to 6 carbon atoms. Transition metal and rare earth metal salts are used as the catalysts.