Journal
OPEN BIOLOGY
Volume 4, Issue 6, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsob.130108
Keywords
mitosis; microtubule; kinetochore
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Funding
- Cancer Research UK Career Development Award
- CambridgeSens Innovation Prize
- Cancer Research UK [9787] Funding Source: researchfish
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Chromosomal instability can arise from defects in chromosome-microtubule attachment. Using a variety of drug treatments, we show that TAO1 kinase is required for ensuring the normal congression of chromosomes. Depletion of TAO1 reduces the density of growing interphase and mitotic microtubules in human cells, showing TAO1's role in controlling microtubule dynamics. We demonstrate the aneugenic nature of chromosome-microtubule attachment defects in TAO1-depleted cells using an error-correction assay. Our model further strengthens the emerging paradigm that microtubule regulatory pathways are important for resolving erroneous kinetochore-microtubule attachments and maintaining the integrity of the genome, regardless of the spindle checkpoint status.
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