Journal
OPEN BIOLOGY
Volume 3, Issue 9, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsob.130088
Keywords
branching; computational modelling; in silico organogenesis
Categories
Funding
- SNF Sinergia grant
- SNF SystemsX RTD NeuroStemX
- SystemsX iPhD grant
- ETH Zurich
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Many organs of higher organisms are heavily branched structures and arise by an apparently similar process of branching morphogenesis. Yet the regulatory components and local interactions that have been identified differ greatly in these organs. It is an open question whether the regulatory processes work according to a common principle and how far physical and geometrical constraints determine the branching process. Here, we review the known regulatory factors and physical constraints in lung, kidney, pancreas, prostate, mammary gland and salivary gland branching morphogenesis, and describe the models that have been formulated to analyse their impacts.
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