Journal
OPEN BIOLOGY
Volume 2, Issue -, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsob.120075
Keywords
innate immunity; Drosophila; host defence
Categories
Funding
- Medical Research Council
- Wellcome Trust
- National Centre for the Replacement Refinement and Reduction of animals in research (NC3Rs)
- Bodossaki Foundation, Greece
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Innate immunity relies entirely upon germ-line encoded receptors, signalling components and effector molecules for the recognition and elimination of invading pathogens. The fruit fly Drosophila melanogaster with its powerful collection of genetic and genomic tools has been the model of choice to develop ideas about innate immunity and host-pathogen interactions. Here, we review current research in the field, encompassing all layers of defence from the role of the microbiota to systemic immune activation, and attempt to speculate on future directions and open questions.
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