Journal
OPEN BIOLOGY
Volume 2, Issue -, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsob.120090
Keywords
single molecule; in vivo; microscopy; super-resolution; fluorescence imaging; fluorescent protein
Categories
Funding
- Royal Society URF
- EPSRC [EP/G061009]
- Oxford Cancer Research Centre Development Fund (CRUK)
- Lawerence Berekely National Laboratories (LBNL)
- EPSRC [EP/G061009/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/G061009/1] Funding Source: researchfish
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In recent years, single molecule experimentation has allowed researchers to observe biological processes at the sensitivity level of single molecules in actual functioning, living cells, thereby allowing us to observe the molecular basis of the key mechanistic processes in question in a very direct way, rather than inferring these from ensemble average data gained from traditional molecular and biochemical techniques. In this short review, we demonstrate the impact that the application of single molecule bioscience experimentation has had on our understanding of various cellular systems and processes, and the potential that this approach has for the future to really address very challenging and fundamental questions in the life sciences.
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