Journal
MOLECULAR BRAIN
Volume 6, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1756-6606-6-15
Keywords
FMRP; Protein synthesis; Synaptic plasticity; Long-term depression; Long-term potentiation; Metabotropic glutamate receptor; Fragile X
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Funding
- NIGMS NIH HHS [T32 GM007484] Funding Source: Medline
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Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these proteins is required for the maintenance and regulation of long-lasting changes in synaptic strength. In this role as a translational inhibitor, FMRP exerts profound effects on synaptic plasticity.
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