Journal
MATERIALS EXPRESS
Volume 3, Issue 3, Pages 201-209Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/mex.2013.1126
Keywords
Carbon Nanoparticles; Fluorescence Imaging; Human Erythrocytes; Haemolysis; Blood Plasma
Funding
- Department of Science and Technology India
- Council of Scientific and Industrial Research New Delhi, India
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We have isolated carbon nanoparticles (CNPs) from bread. A simple oxidative treatment make them water soluble and fluorescent. CNPs exhibit fluorescence over a broad range of excitation wavelengths. These fluorescent CNPs have been susscessfully used for fluorescence imaging of human erythrocytes under 488 and 561 nm bandpass filters. Upon direct interaction with human erythrocytes, these CNPs show similar to 6% haemolysis in 5 h. In the presence of blood plasma, the quantum yield of these water soluble carbon nanoparticles enhances from 2 to 4.5% leading to rise a new phenomenon of auto passivation of CNPs by bio-fluids. Therefore, these fluorescent CNPs can be used as a unique and new type of biomaterial for bioimaging and other biomedical applications.
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