Journal
JOURNAL OF SAUDI CHEMICAL SOCIETY
Volume 17, Issue 3, Pages 337-344Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jscs.2011.10.022
Keywords
Indolin-2-one; Schiff base; Mannich base; Antimicrobial activity
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With the aim of developing potential antimicrobials, a series of novel Ciprofloxacin methylene isatin derivatives incorporating different aromatic aldehydes were synthesized and characterized by FTIR, H-1 NMR, Mass spectroscopy and bases of elemental analysis. In addition, the in vitro antibacterial and antifungal properties were tested against some human pathogenic microorganisms by employing the disc diffusion technique. A majority of compounds were showing activity against several of the microorganisms. The relationship between the functional group variation and the biological activity of the evaluated compounds is discussed. From comparisons of the compounds, 3c was determined to be the most active compound. (C) 2011 King Saud University. Production and hosting by Elsevier B.V. All rights reserved.
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