Journal
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
Volume 66, Issue 3, Pages 221-231Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.vascn.2012.08.169
Keywords
Gonadal hormones; Epigenetics; Heterosexuality; Homosexuality; Postnatal stress; Prenatal stress; Perinatal stress; Sexual differentiation; Social behaviors; Stress; DNA methylation; Hormones
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Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Brazil
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Introduction: Numerous studies employing various animal models have found that perinatal stress, encountered in utero during sensitive developmental stages or shortly after birth, disrupts both sexual differentiation and sexual behavior in offspring. The biochemical, cellular, genetic and epigenetic events which are involved in the organismal response to perinatal stress are currently under investigation. Methods, Results and Discussion: In this review, the reader is introduced to perinatal stressors as a toxicological phenomenon, and several recently characterized epigenetic responses to said stressors are discussed. (C) 2012 Elsevier Inc. All rights reserved.
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