Journal
JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
Volume 2, Issue 3, Pages 253-259Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S1793545809000619
Keywords
Optical Coherence Tomography; non-invasive; mouse embryos; cardiovascular function
Funding
- NHLBI NIH HHS [R01 HL095586, R01 HL095586-01A1, R01 HL095586-02, R01 HL077187] Funding Source: Medline
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Early embryonic imaging of cardiovascular development in mammalian models requires a method that can penetrate through and distinguish the many tissue layers with high spatial and temporal resolution. In this paper we evaluate the capability of Optical Coherence Tomography (OCT) technique for structural 3D embryonic imaging in mouse embryos at different stages of the developmental process ranging from 7.5 dpc up to 10.5 dpc. Obtained results suggest that the collected data is suitable for quantitative and qualitative measurements to assess cardiovascular function in mouse models, which is likely to expand our knowledge of the complexity of the embryonic heart, and its development into an adult heart.
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