Journal
JOURNAL OF GINSENG RESEARCH
Volume 36, Issue 1, Pages 27-39Publisher
KOREAN SOC GINSENG
DOI: 10.5142/jgr.2012.36.1.27
Keywords
Panax ginseng; Ginsenosides; Diabetes mellitus; AMP-activated protein kinase (AMPK)
Funding
- Korea Science and Engineering Foundation
- Korean government (MEST) [R13-2011-019-00000-0]
- National Research Foundation of Korea [과06A2601] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Panax ginseng exhibits pleiotropic beneficial effects on cardiovascular system, central nervous system, and immune system. In the last decade, numerous preclinical findings suggest ginseng as a promising therapeutic agent for diabetes prevention and treatment. The mechanism of ginseng and its active components is complex and is demonstrated to either modulate insulin production/secretion, glucose metabolism and uptake, or inflammatory pathway in both insulin-dependent and insulin-independent manners. However, human studies are remained obscure because of contradictory results. While more studies are warranted to further understand these contradictions, ginseng holds promise as a therapeutic agent for diabetes prevention and treatment. This review summarizes the evidences for the therapeutic potential of ginseng and ginsenosides from in vitro studies, animal studies and human clinical trials with a focus on diverse molecular targets including an AMP-activated protein kinase signaling pathway.
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