Journal
JOURNAL OF GINSENG RESEARCH
Volume 36, Issue 4, Pages 342-353Publisher
KOREAN SOC GINSENG
DOI: 10.5142/jgr.2012.36.4.342
Keywords
Panax ginseng; Ginsenosides; Neuroprotection; Neurodegeneration
Funding
- National Research Foundation of Korea
- Ministry of Education, Science and Technology [20110004973, 2012008505]
- Kyung Hee University [KHU-20100701]
- National Research Foundation of Korea [과06A2101, 2012R1A1A2008505] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Ginseng, the root of the Panax ginseng, has been a popular and widely-used traditional herbal medicine in Korea, China, and Japan for thousands of years. Now it has become popular as a functional health food and is used globally as a natural medicine. Evidence is accumulating in the literature on the physiological and pharmacological effects of P ginseng on neurodegenerative diseases. Possible ginseng- or ginsenosides-mediated neuroprotective mechanisms mainly involve maintaining homeostasis, and anti-inflammatory, anti-oxidant, anti-apoptotic, and immune-stimulatory activities. This review considers publications dealing with the various actions of P ginseng that are indicative of possible neurotherapeutic efficacies in neurodegenerative diseases and neurological disorders such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and amyotrophic lateral sclerosis and multiple sclerosis.
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