Journal
JOURNAL OF DIABETES
Volume 6, Issue 4, Pages 360-368Publisher
WILEY
DOI: 10.1111/1753-0407.12114
Keywords
Chinese pregnant women; gestational diabetes; glucose intolerance; HMW-adiponectin; inflammatory markers; T-adiponectin
Categories
Funding
- Gerald J. and Dorothy R. Friedman New York Foundation for Medical Research
- Chinese-American Medical Society & Chinese-American Independent Practice Association Research Fund
- Yen Family Foundation
Ask authors/readers for more resources
Background: Elevated insulin, C-reactive protein (CRP), tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1 levels and decreased high molecular weight adiponectin (HMW-APN) levels have been reported in Caucasians with gestational diabetes mellitus (GDM). No similar studies have been performed in Chinese women. Methods: Serum samples were obtained 1 h after a 50-g glucose challenge test (1HGCT) from Chinese-American women at 24-28 gestational weeks and total adiponectin (T-APN), HMW-APN, CRP, TNF-alpha, IL-6, and MCP-1 concentrations were measured. Correlation coefficients for glucose (1HGCT), HbA1c, insulin, and body mass index (BMI) were calculated against T-APN, HMW-APN, CRP, TNF-a, IL-6, and MCP-1. Significant P-values were determined using Bonferroni adjustments. Results: Women with GDM had higher insulin and 1HGCT and lower T-APN. In addition, T-APN was lower in non-GDM subjects who had 1HGCT = 135 mg/dL with no abnormal or one abnormal glucose value on the 3-h oral glucose tolerance test. There were no significant differences in HMW-APN and inflammatory marker levels between non-GDM and GDM groups. There were negative correlations between T-APN and 1HGCT, insulin, BMI, and HbA1c, as well as between HMW-APN and 1HGCT, insulin, and BMI. No significant correlations were observed between 1HGCT, HbA1c, insulin, or BMI and CRP, TNF-a, IL-6, or MCP-1. Conclusions: T-APN is reduced in Chinese women with GDM and those without GDM but with evidence of glucose intolerance. Unlike results reported for Caucasians, Chinese-American women with GDM do not exhibit elevated levels of CRP, TNF-a, IL-6, or MCP-1, possibly because Chinese women are relatively leaner compared with Caucasians.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available