Journal
JOURNAL OF DIABETES
Volume 1, Issue 3, Pages 151-162Publisher
WILEY
DOI: 10.1111/j.1753-0407.2009.00030.x
Keywords
diabetes mellitus Type 1 and 2; endothelium-derived contracting factor; endothelium-derived relaxing factor; prostanoid TP receptors; reactive oxygen-derived free radicals
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Funding
- Switzerland National Foundation [3100068118.02]
- Research Grant Council of HK [HKU777507M]
- Research Grants Council [HKU 7524]
- Research Centre of Heart, Brain, Hormonal and Healthy Aging (HBHA) of the University of Hong Kong
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Vascular complications are an important pathological issue in diabetes that lead to the further functional deterioration of several organs. The balance between endothelium-dependent relaxing factors and endothelium-dependent contracting factors (EDCFs) is crucial in controlling local vascular tone and function under normal conditions. Diabetic endothelial dysfunction is characterized by reduced endothelium-dependent relaxations and/or enhanced endothelium-dependent contractions. Elevated levels of oxygen-derived free radicals are the initial source of endothelial dysfunction in diabetes. Oxygen-derived free radicals not only reduce nitric oxide bioavailability, but also facilitate the production and/or action of EDCFs. Thus, the endothelial balance tips towards vasoconstrictor responses over the course of diabetes.
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