Journal
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
Volume 56, Issue 1, Pages 527-531Publisher
SOC CHILENA QUIMICA
DOI: 10.4067/S0717-97072011000100001
Keywords
2,1-Benzothiazine 2,2-dioxides; Schiff bases; Anti-bacterial activity; Methyl anthranilate
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Funding
- Higher Education Commision, Islamabad Pakistan [5000]
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A convenient ultrasound assisted synthesis of new anti-bacterial N-benzylidene-N'-(1-methyl-2, 2-dioxo-2,3-dihydro-1H-2 lambda(6)-benzo[c][1,2]thiazin-4-ylidene)-hydrazines from methyl anthranilate is reported. Methyl anthranilate was reacted with methane sulfonyl chloride, followed by N-alkylation and subsequent base catalyzed cyclization. Hydrazinolysis of the cyclized products followed by their ultrasound mediated condensations with different benzaldehydes yielded the title compounds. Some of these compounds showed good anti-bacterial activity against Pseudomonas aeruginosa, Salmonella typhimurium and Staphylococcus aureus.
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