3.9 Article

Synthesis of o-substituted benzophenones by Grignard reaction of 3-substituted isocoumarins

Journal

JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
Volume 53, Issue 3, Pages 1609-1610

Publisher

SOC CHILENA QUIMICA
DOI: 10.4067/S0717-97072008000300012

Keywords

isocoumarins; diketones; aryl; phenyl magnesium bromide; ether; dry ice

Funding

  1. SAIF
  2. Indian Institute of Science, Bangalore
  3. Spic Science foundation, Tuticorin
  4. Syngene International Limited, Bangalore
  5. NMR
  6. HRMS

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A series of o-substituted benzophenones was prepared by efficient method involving the 3-substituted isocoumarins and phenylmagnesium bromide. The reaction was completed in presence of anhydrous ether under dry ice-solvent bath in few hours with modest to good yields.

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